Table 3.

The factors, levels and results of central composite design-response surface method

Number	A: lecithin (mg)	B: resveratrol (mg)	C: water volume (mL)	Y1: drug loading (%)	Y2: particle size (nm)
1	132.00	70.00	200.00	18.74	309.37
2	67.78	40.27	259.46	8.76	169.93
3	196.22	99.73	259.46	21.20	334.03
4	132.00	70.00	200.00	18.88	309.37
5	196.22	40.27	140.54	6.72	165.77
6	132.00	120.00	200.00	28.97	372.30
7	196.22	99.73	140.54	21.65	307.70
8	24.00	70.00	200.00	29.67	372.93
9	132.00	20.00	200.00	3.65	121.13
10	132.00	70.00	200.00	18.67	301.23
11	132.00	70.00	200.00	18.83	301.23
12	67.78	40.27	140.54	10.66	198.47
13	132.00	70.00	200.00	18.74	274.97
14	67.78	99.73	259.46	30.65	451.87
15	67.78	99.73	140.54	32.13	479.63
16	240.00	70.00	200.00	12.90	200.57
17	132.00	70.00	300.00	14.33	279.83
18	132.00	70.00	100.00	11.65	277.50
19	132.00	70.00	200.00	16.01	269.97
20	196.22	40.27	259.46	4.88	156.17