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. Author manuscript; available in PMC: 2020 Aug 1.
Published in final edited form as: Breast Cancer Res Treat. 2019 May 22;177(1):29–40. doi: 10.1007/s10549-019-05279-9

Figure 6.

Figure 6.

Buttressed analogs as inhibitors of breast tumor growth in athymic nude mice. The 3-Cl, 3,5-Br2 and 3-Cl-5-OCH3 buttressed analogs of DIM-C-pPhOH were administered to athymic nude mice bearing MDA-MB-231 cells at doses of 10 mg/kg/d (A) and 5 mg/kg/d (B), and effects on tumor growth and weight were determined as outlined in the Materials and Methods. The effects of low doses (100 μg – 2 mg/kg/d) of 3-Cl-5-OCH3 on tumor growth (C) and (D) weight were determined as outlined in the Materials and Methods. At least 4 mice were used for each dose. Tumor volumes and weights are means ± SD, and significant (p < 0.05) effects are indicated (*).