Table 2:

Genes commonly mutated in CHIP

Gene	Name	Description
TET2	Ten-eleven-translocation-2	A methylcytosine dioxygenase that catalyzes the conversion of 5-methylcytosine to 5-hydroxymethylcytosine. An epigenetic regulator that can activate or repress transcription.
DNMT3A	DNA methyltransferase 3A	A de novo DNA methyltransferase.
ASXL1	Additional sex combs-like 1	Polycomb chromatin-binding protein that is involve in the transcriptional regulation of Hox genes.
PPMD1	Protein phosphatase, magnesium/manganese-dependant 1D	Protein phosphatase involved in dephosphorylating and inactivating proteins in the DNA damage response pathway.
SF3B1	Splicing factor 3B, subunit 1	A component of the U2 small nuclear riboprotein that binds to the 3’ branch site in pre-mRNA splicing and processing.
SRSF2	Serine/Arginine rich splicing factor 2	Required for 5’ and 3’ spliceosome assembly, splice-site selection, U1 and U2 snRNP interactions with pre-mRNA, and alternative splicing.
TP53	Transformation-related protein 53	Tumor suppressor transcription factor that responds to cellular stress and DNA damage.
JAK2	Janus kinase 2	Receptor tyrosine kinase involved in hematopoietic cytokine signalling and myelopoiesis.