Table 3:

Current Diagnostic Criteria for Clonal Hematopoiesis of Indeterminate Potential (CHIP)

– Absence of definitive morphological evidence of a hematological neoplasm

– Does not meet diagnostic criteria for paroxysmal nocturnal hemoglobinuria (PNH), Monoclonal gammopathy of unknown significance (MGUS) or Monoclonal B-cell lymphocytosis (MBL)

– Presence of a somatic mutation associated with hematological neoplasia at a variant allele fraction of at least 2%

– Odds of progression to overt neoplasia are approximately 0.5-1% per year, similar to MGUS Adapted from Steensma et al. (2)