TABLE 2:
Red Cell Membrane Phospholipid Fatty Acids in Children with SCD and Age- and Race- matched HbAA Controls
| Phospholipid Fraction |
Fatty Acid | HbAA Control (n=18) |
SCD HbSS (n=38) |
p-value |
|---|---|---|---|---|
| PC Fraction | FA-Ratio | 5.39 ± 2.30 ‡4.99 (3.94, 6.63) |
7.35 ± 2.52 6.88 (5.15, 9.10) |
0.003 |
|
AA (nMol/109 RBCs) |
15.59 ± 3.73 ‡14.06 (13.00, 18.52) |
18.00 ± 3.59 17.29 (15.81, 20.57) |
0.039 | |
|
DHA (nMol/109 RBCs) |
*2.72 ± 0.90 2.33 (1.98, 3.75) |
2.22 ± 0.82 2.19 (1.61, 2.53) |
0.047 | |
|
EPA (nMol/109 RBCs) |
0.53 ± 0.44 ‡0.60 (0.01, 0.69) |
0.48 ± 0.48 0.45 (0.01, 0.76) |
ns | |
| PE Fraction | FA-Ratio |
*6.13 ± 2.16 5.94 (4.21, 7.98) |
7.36 ± 1.94 7.21 (5.91, 8.58) |
0.035 |
|
AA (nMol/109 RBCs) |
33.50 ± 16.89 ‡26.42 (21.30, 50.83) |
27.74 ± 6.51 26.57 (24.82, 30.77) |
ns | |
|
DHA (nMol/109 RBCs) |
4.69 ± 2.25 ‡4.29 (2.87, 5.95) |
3.47 ± 1.30 3.50 (2.25, 4.12) |
0.042 | |
|
EPA (nMol/109 RBCs) |
1.00 ± 0.54 ‡1.13 (0.68, 1.32) |
0.54 ± 0.31 0.58 (0.34, 0.73) |
<0.001 |
Results presented are the mean ± SD values (first line), and the median and (1st, and 3rd quartile) levels (second line). Biomarker levels were compared between groups using *unpaired t-test if the data set passed both normality and equal variance tests. ‡Mann-Whitney Rank Sum test was employed if the data set failed normality and/or equal variance tests. Abbreviations used in the Table: AA= arachidonic acid, DHA= docosahexaenoic acid, EPA= eicosapentaenoic acid, PC= phosphatidylcholine, PE= phosphatidylethanolamine, FA-Ratio= fatty acid ratio (ratio of AA to DHA plus EPA), ns= not significant