Skip to main content
. 2019 Aug;60(8):1124–1133. doi: 10.2967/jnumed.118.217240

TABLE 2.

Radiation Dosimetry and Clearance Kinetics Parameters for 225Ac-DOTA-MC1RL in Non–Tumor-Bearing BALB/c Mice

Parameter Blood Brain Heart Intestine Kidney Liver Lung Muscle Skin Spleen
225Ac
 Initial activity/organ (kBq) ND 0.0065 0.0161 1.9113 0.7647 7.6597 0.0512 0.0044 0.0483 0.0426
 Effective decay rate constant (h−1) ND 0.0070 0.0030 0.0060 0.0060 0.0040 0.0030 0.0030 0.0050 0.0030
 Effective decay half-life (d) ND 4.1259 9.6270 4.8135 4.8135 7.2203 9.6270 9.6270 5.7762 9.6270
 Accumulated activity/organ (kBq × h) ND 0.7621 3.8089 260.3419 104.1599 1484.6038 12.1242 1.0529 7.7927 10.0784
 Absorbed dose/injected activity (Gy/kBq) ND 0.0002 0.0023 0.0102 0.0300 0.1485 0.0042 0.0004 0.0024 0.0092
221Fr
 Initial activity/organ (kBq) 0.0153 0.0222 0.0349 1.9927 1.3795 8.4464 0.0723 0.0211 0.0705 0.0647
 Effective decay rate constant (h−1) 0.0010 0.0030 0.0050 0.0070 0.0080 0.0040 0.0020 0.0030 0.0040 0.0040
 Effective decay half-life (d) 28.8811 9.6270 5.7762 4.1259 3.6101 7.2203 14.4406 9.6270 7.2203 7.2203
 Accumulated activity/organ (kBq × h) 5.6907 5.2622 5.6292 232.2869 139.2517 1637.0734 21.2642 4.9899 13.6614 12.5317
 Absorbed dose/injected activity (Gy/kBq) 0.0022 0.0013 0.0037 0.0098 0.0434 0.1770 0.0080 0.0018 0.0045 0.0124
217At
 Initial activity/organ (kBq) 0.0153 0.0222 0.0349 1.9927 1.3795 8.4464 0.0723 0.0211 0.0705 0.0647
 Effective decay rate constant (h−1) 0.0010 0.0030 0.0050 0.0070 0.0080 0.0040 0.0020 0.0030 0.0040 0.0040
 Effective decay half-life (d) 28.8811 9.6270 5.7762 4.1259 3.6101 7.2203 14.4406 9.6270 7.2203 7.2203
 Accumulated activity/organ (kBq × h) 5.6907 5.2622 5.6292 232.2869 139.2517 1637.0734 21.2642 4.9899 13.6614 12.5317
 Absorbed dose/injected activity (Gy/kBq) 0.0025 0.0014 0.0042 0.0110 0.0486 0.1983 0.0090 0.0021 0.0050 0.0139
213Bi
 Initial activity/organ (kBq) 0.0236 0.0195 0.0309 1.8886 1.0318 6.5122 0.0717 0.0152 0.0627 0.0511
 Effective decay rate constant (h−1) 0.0010 0.0010 0.0020 0.0050 0.0040 0.0040 0.0020 0.0020 0.0030 0.0030
 Effective decay half-life (d) 28.8811 28.881 14.4406 5.7762 7.2203 7.2203 14.4406 14.4406 9.6270 9.6270
 Accumulated activity/organ (kBq × h) 8.7917 7.2573 9.0914 304.6111 199.9839 1262.1858 21.0948 4.4603 14.8376 12.1064
 Absorbed dose/injected activity (Gy/kBq) 0.0001 0.0000 0.0001 0.0002 0.0012 0.0025 0.0001 0.0000 0.0001 0.0002
213Po
 Initial activity/organ (kBq) 0.0236 0.0195 0.0309 1.8886 1.0318 6.5122 0.0717 0.0152 0.0627 0.0511
 Effective decay rate constant (h−1) 0.0010 0.0010 0.0020 0.0050 0.0040 0.0040 0.0020 0.0020 0.0030 0.0030
 Effective decay half-life (d) 28.8811 28.881 14.4406 5.7762 7.2203 7.2203 14.4406 14.4406 9.6270 9.6270
 Accumulated activity/organ (kBq × h) 8.7917 7.2573 9.0914 304.6111 199.9839 1262.1858 21.0948 4.4603 14.8376 12.1064
 Absorbed dose/injected activity (Gy/kBq) 0.0044 0.0023 0.0079 0.0168 0.0811 0.1778 0.0103 0.0021 0.0063 0.0156
Total absorbed dose/injected activity (Gy/kBq) 0.0092 0.0053 0.0183 0.0481 0.2042 0.7042 0.0317 0.0064 0.0182 0.0512

ND = not detected.