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. 2019 Aug;60(8):1124–1133. doi: 10.2967/jnumed.118.217240

TABLE 3.

Radiation Dosimetry and Clearance Kinetics for 225Ac-DOTA-MC1RL in SCID Mice Bearing MEL270 Tumors

Parameter Blood Bone Brain Heart Intestine Kidney Liver Lung Muscle Skin Spleen Tumor
225Ac
 Initial activity/organ (kBq) 0.0010 0.0172 0.0031 0.0151 0.3026 0.6417 4.8193 0.0265 0.0042 0.0242 0.0228 0.0518
 Effective decay rate constant (h−1) 0.0010 0.0030 0.0020 0.0050 0.0130 0.0050 0.0060 0.0050 0.0020 0.0020 0.0040 0.0080
 Effective decay half-life (d) 28.8811 9.6270 14.4406 5.7762 2.2216 5.7762 4.8135 5.7762 14.4406 14.4406 7.2203 3.6101
 Accumulated activity/organ (kBq × h) 0.2726 3.2443 0.6873 2.1154 16.7417 89.9040 588.513 3.7089 0.9236 5.3441 3.6979 4.9055
 Absorbed dose/injected activity (Gy/kBq) 0.0001 0.0041 0.0003 0.0020 0.0012 0.0273 0.0662 0.0025 0.0007 0.0010 0.0107 0.0045
221Fr
 Initial activity/organ (kBq) 0.0036 0.0185 0.0059 0.0192 0.2655 0.6167 4.4828 0.0495 0.0071 0.0362 0.0257 0.0806
 Effective decay rate constant (h−1) 0.0017 0.0030 0.0010 0.0030 0.0090 0.0040 0.0060 0.0040 0.0020 0.0020 0.0010 0.0070
 Effective decay half-life (d) 16.9889 9.6270 28.8811 9.6270 3.2090 7.2203 4.8135 7.2203 14.4406 14.4406 28.881 4.1259
 Accumulated activity/organ (kBq × h) 0.8370 3.4960 1.5396 3.6259 22.3311 99.8475 547.425 8.0162 1.5699 8.0166 6.7303 8.6407
 Absorbed dose/injected activity (Gy/kBq) 0.0002 0.0047 0.0007 0.0037 0.0017 0.0328 0.0666 0.0058 0.0014 0.0017 0.0211 0.0086
217At
 Initial activity/organ (kBq) 0.0036 0.0185 0.0059 0.0192 0.2655 0.6167 4.4828 0.0495 0.0071 0.0362 0.0257 0.0806
 Effective decay rate constant (h−1) 0.0017 0.0030 0.0010 0.0030 0.0090 0.0040 0.0060 0.0040 0.0020 0.0020 0.0010 0.0070
 Effective decay half-life (d) 16.9889 9.6270 28.8811 9.6270 3.2090 7.2203 4.8135 7.2203 14.4406 14.4406 28.881 4.1259
 Accumulated activity/organ (kBq × h) 0.8370 3.4960 1.5396 3.6259 22.3311 99.8475 547.425 8.0162 1.5699 8.0166 6.7303 8.6407
 Absorbed dose/injected activity (Gy/kBq) 0.0003 0.0053 0.0007 0.0041 0.0019 0.0367 0.0746 0.0065 0.0015 0.0019 0.0236 0.0097
213Bi
 Initial activity/organ (kBq) 0.0016 0.0133 0.0027 0.0082 0.2160 0.5664 3.9089 0.0175 0.0017 0.0240 0.0131 0.0381
 Effective decay rate constant (h−1) 0.0013 0.0020 0.0007 0.0040 0.0100 0.0040 0.0060 0.0060 0.0020 0.0050 0.0030 0.0060
 Effective decay half-life (d) 22.2163 14.4406 41.2588 7.2203 2.8881 7.2203 4.8135 4.8135 14.4406 5.7762 9.6270 4.8135
 Accumulated activity/organ (kBq × h) 0.4096 2.9358 0.7531 1.3342 16.2384 91.7024 477.346 2.1354 0.3859 3.3617 2.4736 4.6565
 Absorbed dose/injected activity (Gy/kBq) 2.20E-06 7.39E-05 5.96E-06 2.51E-05 2.32E-05 5.61E-04 1.08E-03 2.88E-05 6.19E-06 1.32E-05 1.44E-04 8.68E-05
213Po
 Initial activity/organ (kBq) 0.0016 0.0133 0.0027 0.0082 0.2160 0.5664 3.9089 0.0175 0.0017 0.0240 0.0131 0.0381
 Effective decay rate constant (h−1) 0.0013 0.0020 0.0007 0.0040 0.0100 0.0040 0.0060 0.0060 0.0020 0.0050 0.0030 0.0060
 Effective decay half-life (d) 22.2163 14.4406 41.2588 7.2203 2.8881 7.2203 4.8135 4.8135 14.4406 5.7762 9.6270 4.8135
 Accumulated activity/organ (kBq × h) 0.4096 2.9358 0.7531 1.3342 16.2384 91.7024 477.346 2.1354 0.3859 3.3617 2.4736 4.6565
 Absorbed dose/injected activity (Gy/kBq) 0.0002 0.0052 0.0004 0.0018 0.0016 0.0392 0.0756 0.0020 0.0004 0.0009 0.0101 0.0061
Total absorbed dose/injected activity (Gy/kBq) 0.0007 0.0193 0.0021 0.0115 0.0065 0.1366 0.2842 0.0168 0.0040 0.0056 0.0656 0.0290