Skip to main content
. 2019 Jun 24;116(31):15475–15484. doi: 10.1073/pnas.1905488116

Fig. 2.

Fig. 2.

Structures of UAE/Ub complexes in open and closed states. (A) Cartoon representations of crystal structures of UAE Ub-AMSN/Mg2+/PPi in the open E1 conformation and UAE∼Ub-AVSN in the closed E1 conformation. IAD domains are in blue; AAD, FCCH, and SCCH domains are in shades of pink; Ub/SUMO is in yellow; UFD domain is in red; and active site cysteine residues are in green. The cross-over loop comprising residues 583 to 591 and reentry loop comprising residues 849 to 853 are included and colored the same as the SCCH domain. Representations were made with PyMOL (The PyMOL Molecular Graphics System, Version 2.0; Schrödinger, LLC.). (B) Schematic illustrations depicting states of UAE shown in A.