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Active sites of UAE/Ub complexes in open and closed states. Shown are close-ups of the active sites of UAE Ub/ATP/Mg2+ (PDB ID code 4II3), UAE Ub-AMSN/Mg2+/PPi, and UAE∼Ub-AVSN, with regions shown in ribbon cartoon with side chains and relevant backbone atoms shown in stick representation. Colors are as in Fig. 2.
