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. 2019 Jul 15;116(31):15524–15533. doi: 10.1073/pnas.1900391116

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Fig. 5. — (A) Significantly fused genes: those paired with multiple partners (counted by counting distinct fusion pairs). (B) Significantly fused genes are observed at rates higher than expected by chance; genes with k $>$ 10 partners would be unlikely to occur by random assortment of genes into fusions (FDR-corrected P $<$ 0.01). (C) Genes with the highest number of distinct gene partners. (D) GO enrichment analysis of significantly fused genes shows enrichment in pathways known to regulate cancer growth. (E) Tumors are highly enriched for extreme fusions involving significantly fused genes.