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. 2019 Jul 17;116(31):15505–15513. doi: 10.1073/pnas.1906253116

Fig. 4.

Fig. 4.

Comparison of type I receptor engagement across the TGFβ family. (A) Ribbon showing 1 type I and 1 type II for GDF11/ActRIIB/Alk5 (PDB ID code 6MAC) and BMP2/ActRIIA/Alk3 (PDB ID code 2GOO), with orientation consistent with alignment of monomer A of the ligand. (B) Knob-in-hole motif observed between F108 of Alk3 and BMP2. (C and D) Comparison of the ligand fingertip-type I interface (C) and the ligand wrist helix cap (D) between GDF11/Alk5 (Left) and BMP2/Alk3 (Right). (E) Ligand surface representation of type I binding interface, with interacting residues on monomer A colored magenta and those on monomer B colored pink. Buried surface area calculations for each of the interfaces are shown as determined by using jsPISA.