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. 2019 Jun 29;18(16):1908–1924. doi: 10.1080/15384101.2019.1632641

Figure 7.

Figure 7.

LINC00968 up-regulates the expression of PROX1 by decreasing hsa-miR-423-5p. (a), mRNA expression of PROX1 after overexpression of LINC00968 in MDA-MB-231 cells determined by RT-qPCR. (b), PROX1 protein expression in MDA-MB-231 cells overexpressing LINC00968 measured by Western blot analysis; (c), the mRNA expression of PROX1 corresponding to different concentrations of Lenti-LINC00968 and Lenti-LINC00968-mut when co-transfected with hsa-miR-423-5p mimic into MDA-MB-231 cells determined by RT-qPCR. (d), mRNA expression of PROX1 in MCF-7 cells overexpressing LINC00968 determined by RT-qPCR. (e), Western blot analysis of PROX1 protein in MCF-7 cells overexpressing LINC00968. (f), the mRNA expression of PROX1 corresponding to different concentrations of Lenti-LINC00968 and Lenti-LINC00968-mut in the presence of hsa-miR-423-5p mimic determined by RT-qPCR. * p < 0.05, vs. the Lenti-NC group (cells transfected with Lenti-NC). The measurement data were expressed as mean ± standard deviation. Data between two groups were compared by unpaired t-test. The experiment was repeated three times.