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. 2019 Jul 10;18(16):1868–1881. doi: 10.1080/15384101.2019.1632133

Figure 4.

Figure 4.

Brain tissues of MCAO-R mice exhibit decreased miR-199b-3p but activated MAPK/ERK/EGR1 axis. A, the miR-199b-3p expression and mRNA expression of EGR1, p38MAPK, Bcl-2, ERK and Bax in brain tissues of sham and MCAO-R mice examined by RT-qPCR; B, the protein expression of EGR1, p38MAPK, ERK, Bcl-2 and Bax, and the extent of p38MAPK and ERK phosphorylation in brain tissues of mice in the sham and MCAO-R group; C, grey values of EGR1, p38MAPK, p-p38MAPK, ERK, p-ERK, Bcl-2 and Bax protein bands in brain tissues of mice in the sham and MCAO-R group assessed by western blot analysis. *, p< 0.05 vs. the sham group; miR-199b-3p, microRNA-199b-3p; MCAO-R, middle cerebral artery occlusion-reperfusion; EGR1, early growth response 1; p38MAPK, p38 mitogen-activated protein kinase; p-p38MAPK, p-p38 mitogen-activated protein kinase; ERK, extracellular signal-regulated kinase; p-ERK, p-extracellular signal-regulated kinase; Bcl-2, B cell lymphoma-2; Bax, BCL (B Cell Lymphoma)-Associated X; GAPDH, glyceraldehyde-3-phosphate dehydrogenase.