Upregulated miR-98 inhibited TNF-α, IL-6 expression and promoted IL-10 expression and alleviated histopathological changes of liver tissues in mice of each group. (a) Liver histopathological changes in each group of mice (HE staining, × 200, scale bar = 50 μm), N = 15. (b) The mRNA expression levels of inflammatory factors in liver tissues of mice in each group; (c) Protein expression levels of TNF-α in liver tissues of mice in each group; (d) Protein expression levels of IL-6 in liver tissues of mice in each group; (e) Protein expression levels of IL-10 in liver tissue of each group of mice; * P < 0.05 vs. the sham group; # P< 0.05 vs. the CLP group. N = 15, the data was expressed in the form of mean ± standard deviation; one-way ANOVA was used for data analysis. LSD-t test was used after pairwise comparison.