Figure 9.

Downregulated miR-98, upregulated HMGA2 and NF-κB pathway-related proteins are found in lung tissues of mice with sepsis, and upregulated miR-98 decreased PaCO₂ and increased pH and PaO₂ in mice with sepsis. (a) Expression of miR-98 and HMGA2 mRNA in lung tissues of mice in each group; (b) Immunoblots of HMGA2 and NF-κB protein in lung tissues of mice in each group; (c) HMGA2 and NF-κB protein expression in lung tissues of mice in each group; (d) Comparison of the pH levels of the mice in each group; (e) Comparison of the levels of PaO₂ in each group of mice; (f) Comparison of the levels of PaCO₂ in each group of mice; * P < 0.05 vs. the sham group; # P< 0.05 vs. the CLP group. N = 15, the data was expressed in the form of mean ± standard deviation; one-way ANOVA was used for data analysis. LSD-t test was used after pairwise comparison.