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. 2019 Jul 7;18(16):1882–1892. doi: 10.1080/15384101.2019.1632134

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Figure 5. — Downregulation of XIST-suppressed cell growth, invasion, and migration in neuroblastoma via increasing DKK1. SK-N-BE (2) and SH-SY5Y cells were allocated into four groups: siRNA-control, siRNA-XIST, siRNA-XIST+NC, and siRNA-XIST+siRNA-DKK1. (a) The colony formation of Neuroblastoma cells SK-N-BE (2) and SH-SY5Y was determined with soft agar assay. (b) The CCK-8 assay was carried out to estimate SK-N-BE (2) and SH-SY5Y cells proliferation. (c) Neuroblastoma cells SK-N-BE (2) and SH-SY5Y migration was evaluated by Transwell assay. (d) Transwell assay was performed to assess the invasion of neuroblastoma cells SK-N-BE (2) and SH-SY5Y. **p< 0.05 compared with siRNA-control. ^##p< 0.05 compared with siRNA-XIST+NC.