SNHG6 promoted the proliferation and viability of HCC cells. (a) Colony numbers in SNHG6 group and vector group were counted and compared. Overexpression of SNHG6 showed a significant increase in the number of hepatoma cells. (**P< 0.01, compared with Vector group) (b) Migration and invasion rate of HepG2 and Hep3b cells in different transfection groups, the migration cells and invasion cells per field suggested the migration and invasion rate of cells. (**P< 0.01, compared with Vector group) (c) Cell cycle analysis showed cell cycle was activated by SNHG6 (*P< 0.05, **P< 0.01, compared with Vector group). Every experiment was performed for 3 times at least.