Table 5:
Summary of tissue toxicity of silica nanoparticles as a function of size, porosity and time. ** and * mean all the mice (3 out of 3) or 1 or 2 out of 3 mice, respectively, showed abnormal lesions in related tissue, “x” means the tissue of all the mice that received the indicated nanoparticles looked healthy.
| Affected organs based on histology results | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Nanoparticles | 10 days | 60 days | 180 days | ||||||
| Liver | Lung | Spleen | Liver | Lung | Spleen | Liver | Lung | Spleen | |
| Stöber SNPs500 (♀: 303 ± 4 mg.kg−1) (♂: 300 ± 13 mg.kg−1) |
** | ** | ** | ** | * | * | * | x | X |
| Mesoporous SNPs500 (♀: 95 ± 2 mg.kg−1) (♂: 40 ± 2 mg.kg−1) |
** | ** | ** | * | x | x | * | x | x |
| Stöber SNPs50 (♀: 103 ± 11 mg.kg−1) (♂: 100 ± 6 mg.kg−1) |
** | x | x | x | x | ** | x | x | X |