Table 2. Changes in Serum Uric Acid, eGFR and Urinary Protein After the Start of Topiroxostat Treatment.
| After 3 months |
After 6 months |
|||||||
|---|---|---|---|---|---|---|---|---|
| N | Baseline | After 3 month | P values | N | Baseline | After 6 month | P values | |
| Serum uric acid (mg/dL) | 35 | 8.3 ± 1.4 | 6.5 ± 2.0 | < 0.001 | 26 | 8.2 ± 1.3 | 6.2 ± 1.8 | < 0.001 |
| eGFR (mL/min/1.73m2) | 36 | 49.1 ± 18.8 | 50.3 ± 20.0 | 0.368 | 28 | 47.6 ± 19.1 | 49.9 ± 20.0 | 0.063 |
| Positivity for urinary protein (n, %) | 23 | 13 (56.5%) | 11 (47.8%) | 0.002 | 23 | 13 (56.5%) | 8 (34.8%) | 0.003 |
The paired t-test and Fisher’s exact probability test were used to statistically analyze comparison in serum uric acid and eGFR, and comparison in positive rate of urinary protein, respectively.