. Author manuscript; available in PMC: 2020 Jul 1.

Published in final edited form as: Curr Opin Urol. 2019 Jul;29(4):350–356. doi: 10.1097/MOU.0000000000000641

Table 1.

Classification of bladder tumors

	Characteristics	TCGA					MDA			UNC
	Characteristics	Luminal-papillary	Luminal-infiltrated	Luminal	Basal-squamous	Neuronal	Luminal	p53-like	Basal	Luminal	Basal
Luminal characteristics	High expression of FGFR3	✓✓	✓✓	✓✓			✓✓			✓✓
	Low molecular weight keratins (KRT20)	✓✓	✓✓	✓✓			✓✓	✓✓		✓✓
	High urothelial differentiation (FOXA1, GATA3, PPARG)	✓✓	✓✓	✓✓			✓✓	✓✓		✓✓
	High uroplakins (UPK2, UPK1A)	✓✓	✓✓	✓✓						✓✓
	High immune infiltrates		✓✓		✓✓			✓✓
	High expression of immune markers (PD1, PDL1)		✓✓		✓✓			✓✓
	Papillary morphology	✓✓
Basal characteristics	High molecular weight keratins (KRT5, KRT6, KRT14)				✓✓	✓✓			✓✓		✓✓
	More stem-like phenotype				✓✓	✓✓			✓✓		✓✓
	Upregulated EMT markers		✓✓	✓✓	✓✓	✓✓			✓✓		✓✓
	RB1 pathway alteration				✓✓	✓✓			✓✓		✓✓
	p53 mutations				✓✓	✓✓					✓✓
	p63 activation				✓✓				✓✓
	High squamous differentiation markers				✓✓	✓✓			✓✓
	High neuronal differentiation					✓✓
	Prognosis	Good	Intermediate	Intermediate	Poor	Poor	Good	Intermediate	Poor	Good	Poor