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. Author manuscript; available in PMC: 2019 Aug 5.
Published in final edited form as: Nat Rev Drug Discov. 2018 Nov 9;18(1):59–82. doi: 10.1038/nrd.2018.180

Table 1.

Survey of NMR Studies of GPCRs

GPCR NMR Labels Expression System Membrane Mimetic ref.
β2AR 13CH3-Lys Sf9 DDM 116
β2AR 19F-TET Sf9 DDM/CHS 112
β2AR 13CH3-Met expresSF+ DDM 113
β2AR 19F-BTFA Sf9 DDM and LMNG 117
β2AR 13CH3-Met Sf9 DDM 118
β2AR 19F-BTFA Sf9 LMNG 119
β2AR 19F-TET Sf9 DDM/CHS 120
β2AR 13CH3-Met, 2H expresSF+ nanodisc 121
β2AR 19F-BTFMA Sf9 DDM 122
β2AR-T4L 19F-TET Sf9 DDM/CHS 123
β2AR 13CH3-Met, 2H Cterm-2H, 13C, 15N expresSF+ + E. coli (segmental label) nanodisc 124
β1AR 15N-Val High Five DM 114
β1AR 13CH3-Met Sf9/Sf21 LMNG 115
BLT2 13CH3-Ile E. coli nanodisc 130
A2AAR 19F-BTFMA P. pastoris LMNG/CHS 125
A2AAR 13CH3-Ile, 2H P. pastoris DDM 126
A2AAR u-15N, ~70% 2H P. pastoris LMNG/CHS 127
A2AAR 19F-BTFMA P. pastoris LMNG/CHS 131
MOR 13CH3-Met, 2H expresSF+ LMNG/CHS 128
MOR 13CH3-Lys Sf9 LMNG/CHS 129