Table 2.
The LOECs for the measured endpoints from the medaka multi-generational tests on chemicals that are estrogen receptor agonists.
| Estrogen Receptor Agonist | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Endpoint | E2 CERI | 4tOP EPA | 4tOP NIES | o,p’-DDT CERI | CMP EPA | |||||
| % Change | LOEC | % Change | LOEC | % Change | LOEC | % Change | LOEC | % Change | LOEC | |
| Fecundity | −30% | 28 ng/L | −90% | 102 μg/L | −80% | 100 μg/L | >1.9 μg/L | > 345 μg/L | ||
| Fertility | −60% | 28 ng/L | −70% | 51 μg/L | −99% | 100 μg/L | −50% | 1.9 μg/L | > 345 μg/L | |
| Hatch | > 84 ng/L | −50% | 102 μg/L | −20% | 25 μg/L | >1.9 μg/L | > 345 μg/L | |||
| VTG | 410000 | 28 ng/L | 16800% | 25 μg/L | 400% | 6.25 μg/L | 200% | 0.22 μg/L | 40% | 345 μg/L |
| SSC | −94% | 28 ng/L | −50% | 6 μg/L | −90% | 6.25 μg/L | −40% | 1.9 μg/L | > 345 μg/L | |
| Weight | > 84 ng/L | 20% | 51 μg/L | 20% | 25 μg/L | >1.9 μg/L | > 345 μg/L | |||
| Length | > 84 ng/L | 10% | 13 μg/L | >100 μg/L | >1.9 μg/L | −10% | 165 μg/L | |||
| Larval survival | NA | NA | NA | NA | NA | NA | >1.9 μg/L | > 345 μg/L | ||
| Subadult survival | > 84 ng/L | > 102 μg/L | >100 μg/L | >1.9 μg/L | > 345 μg/L | |||||
| Adult survival | > 84 ng/L | > 102 μg/L | −70% | 100 μg/L | >1.9 μg/L | > 345 μg/L | ||||
Each LOEC is color-coded with red representing a statistically significant decrease in the measurement as compared to controls and green representing a statistically significant increase in the measurement as compared to controls. No color is used when a LOEC was not observed. The percent change is also listed to provide information on the magnitude of the observed response.