Table 3.
The LOEC for each of the measured endpoints for those medaka multi-generational tests that used chemicals that were not estrogen receptor agonists (i.e., ER antagonist, AR agonist, AR antagonist, or steroid inhibitor).
| ER Antagonist | AR Agonist | AR Antagonist | Steroid Inhibitor | |||||
|---|---|---|---|---|---|---|---|---|
| Endpoint | Tamoxifen NIES | 17β-trenbolone EPA | Vinclozolin EPA | Prochloraz EPA | ||||
| % Change | LOEC | % Change | LOEC | % Change | LOEC | % Change | LOEC | |
| Fecundity | −60% | 20 μg/L | −100% | 32 ng/L | −98% | 253 μg/L | −70% | 25 μg/L |
| Fertility | −10% | 10 μg/L | −50% | 13 ng/L | −100% | 253 μg/L | > 41 μg/L | |
| Hatch | −20% | 2.5 μg/L | > 84 ng/L | > 253 μg/L | −30% | 25 μg/L | ||
| VTG | 2000% | 1.3 μg/L | −60% | 32 ng/L | 2300% | 136 μg/L | −96% | 9 μg/L |
| SSC | −30% | 10 μg/L | 0 to 39 | 32 ng/L | −49% | 33 μg/L | −30% | 9 μg/L |
| Weight | −30% | 20 μg/L | > 84 ng/L | 20% | 33 μg/L | −30% | 9 μg/L | |
| Length | −20% | 20 μg/L | > 84 ng/L | 10% | 70 μg/L | −10% | 9 μg/L | |
| Larval survival | NA | NA | NA | −20% | 33 μg/L | −60% | 25 μg/L | |
| Subadult survival | NA | > 84 ng/L | > 253 μg/L | > 25 μg/L | ||||
| Adult survival | >20 μg/L | > 84 ng/L | > 253 μg/L | > 41 μg/L | ||||
Each LOEC is color-coded with red representing a statistically significant decrease in the measurement as compared to controls and green representing a statistically significant increase in the measurement as compared to controls. No color is used when a LOEC was not observed. The percent change is also listed to provide information on the magnitude of the observed response.