Table 2. Frequencies of potential D-interactions with risk of toxicity, categorized according to potential clinical effect.

Potential adverse effect	Frequency
Serotonin toxicity and/or anticholinergic side effects	87
SSRI—SSRIa	84
Other (frequency <5)	3
Cardiac arrhythmias	27
Potassium—spironolactone/amiloride	19
Verapamil/diltiazem—beta blockerb	6
Other (frequency <5)	2
Bleeding	24
Warfarin—ASA low dose	14
Warfarin—metronidazole/sulfamethoxazole	6
Other (frequency <5)	4
Sedation	9
Opioidc - phenobarbital	5
Other (frequency <5)	4
Immunosuppressant toxicity	7
Tacrolimus—itraconazole/posaconazole	5
Other (frequency <5)	2
Other adverse effect (frequency < 5)	13
Total adverse effect	167

Potential clinical effects and summarized frequencies in bold. For each group interaction pairs with a frequency <5 are summarized as other. Groups of potential interactions with a frequency <5 are summarized as other. SSRI selective serotonin reuptake inhibitor, ASA acetylsalicylic acid.

^a Sertraline, fluoxetine, paroxetine, escitalopram, citalopram.

^b Metoprolol, propranolol, bisoprolol.

^c Oxycodone, morphine, codeine.