Table 3. Frequencies of potential D-interactions with risk of reduced treatment effect, categorized according to potential clinical effect.

Potential reduced effect	Frequency
Reduced anti-infective effect	73
Quinolone/tetracyclinea - metal ionb	69
Other (frequency <5)	4
Reduced analgesic effect	39
Ethylmorphine—fluoxetine	18
Codeine/tramadol—fluoxetine/paroxetine	14
Other (frequency <5)	7
Reduced contraceptive effect	37
Carbamazepine—gestagen/estrogenc	15
Oxcarbazepine—gestagen/estrogend	17
Other (frequency <5)	5
Reduced benzodiazepine effect	14
Diazepam—carbamazepine	13
Other (frequency <5)	1
Reduced neuroleptic effect	10
Risperidone—carbamazepine	8
Other (frequency <5)	2
Other reduced effect (frequency < 5)	8
Total reduced effect	181

Potential clinical effects and summarized frequencies in bold. For each group interaction pairs with a frequency <5 are summarized as other. Groups of potential interactions with a frequency <5 are summarized as other.

^a Ciprofloxacin, doxycycline, lymecycline, norfloxacin, tetracycline.

^b Calcium, magnesium, iron, aluminium, zinc.

^c Medroxyprogesterone, desogestrel, ethinylestradiol, drospirenone, etonogestrel, norethisterone, levonorgestrel, norelgestromin.

^d Medroxyprogesterone, ethinylestradiol, desogestrel, norethisterone, levonorgestrel, norelgestromin.