. 2019 Jul 17;4(7):12259–12270. doi: 10.1021/acsomega.9b01557

Table 1. Anti-Alzheimer’s Disease Activity of Bromophenols from S. latiuscula^a.

	50% enzyme inhibition concentration (IC₅₀, μM) (mean ± SD)^b
compounds	AChE (n = 3)	BChE (n = 3)	BACE1 (n = 3)	GSK-3β (n = 3)
MeOH extract^d	195.71 ± 5.07	103.16 ± 3.51	109.59 ± 3.69	219.05 ± 6.21
2,3,6-tribromo-4,5-dihydroxybenzyl alcohol	7.31 ± 0.25^f	8.95 ± 2.18^g	5.16 ± 0.60^f	229.42 ± 12.05^e
2,3,6-tribromo-4,5-dihydroxybenzyl methyl ether	9.61 ± 0.35^e	14.41 ± 0.27^f	4.79 ± 0.82^g	140.01 ± 15.08^f
bis-(2,3,6-tribromo-4,5-dihydroxybenzyl) ether	2.66 ± 0.24^g	4.03 ± 0.15^h	2.32 ± 0.10^h	56.46 ± 2.48^g
berberine^c	1.17 ± 0.09^h	26.15 ± 0.27^e
quercetin^c			25.21 ± 3.12^e
luteolin^c				5.42 ± 0.19^h
SB-415286^c				0.11 ± 0.01ⁱ

Note: Means with different superscripts (e−i) within a column are significantly different with Duncan’s test at p < 0.05.

The 50% inhibitory concentration (IC₅₀) values were calculated from a log dose inhibition curve and expressed as mean ± SD of triplicate experiments.

Used as reference controls (SB-415286; 3-[(3-chloro-4-hydroxyphenyl)-amino]-4-(2-nitrophenyl)-1H-pyrrol-2,5-dione).

IC₅₀ values are expressed in μg/mL.

Table 1. Anti-Alzheimer’s Disease Activity of Bromophenols from S. latiusculaa.