Table 2. Kinetic Studies of Bromophenols from S. latiuscula.
AChE |
BChE |
BACE1 |
||||
---|---|---|---|---|---|---|
compounds | inhibition typea | Ki (μM)b | inhibition typea | Ki (μM)b | inhibition typea | Ki (μM)b |
1 | mixed | 0.58 | competitive | 1.15 | noncompetitive | 3.10 |
2 | mixed | 0.71 | competitive | 0.51 | noncompetitive | 0.70 |
3 | mixed | 0.64 | competitive | 0.37 | competitive | 1.24 |
Inhibition type was determined by the Lineweaver–Burk plot.
Inhibition constant was determined by the Dixon plot.