Figure 2.

Effect of nanoparticles on Tau PHF assembly. The effect of three nanoparticles was tested for the inhibitory activity on Tau aggregation. (A) Thioflavin S (ThS) fluorescence was found to increase at the initial time points for treated as well as control samples. Further, the time-dependent decrease in intensity was observed in the treated samples. (B) Comparative analysis of the end time point fluorescence showed maximum inhibition of PHF assembly by PC-CdS NPs. (C) ThS fluorescence showed a concentration-dependent decrease with increase in the concentration of PC-Fe₃O₄ NPs. (D) The highest concentration of PC-Fe₃O₄ NPs (1 mg/mL) showed 49% inhibition of aggregation propensity of hTau40^WT. (E) Concentration-dependent inhibition of Tau aggregation by PC-CdS NPs showed a rapid decrease in ThS fluorescence. (F) PC-CdS NPs (1 mg/mL) treatment shows 63% inhibition of Tau PHF assembly. (The values are mean ± standard deviation of three independent experiments.)