Table 2. In Vitro Synergistic Anti-candida Activity of BG8.
MIC alone
(μM) |
MIC in combination (μM) |
|||||
---|---|---|---|---|---|---|
compound | BG8 | FLC | BG8 | FLC | FICIa | mode of interaction |
C. albicans (ATCC 90028) | 23.7 | 51.0 | 5.29 | 12.7 | 0.253 | synergy |
C. albicans D15.9a | 23.7 | 3265 | 11.86 | 816 | 0.250 | synergy |
FICI = fractional inhibitory concentration index; synergy and antagonism were defined by FICI ≤ 0.5 and >4, respectively. Indifference was defined by 0.5 < FICI ≤ 4.