Table 3. In Vitro Synergistic Anti-candida Activity of BG10.
MIC alone (μM) |
MIC in combination (μM) |
|||||
---|---|---|---|---|---|---|
compound | BG10 | FLC | BG10 | FLC | FICIa | mode of interaction |
C. albicans (ATCC 90028) | 21.8 | 51.0 | 2.73 | 6.36 | 0.127 | synergy |
C. albicans D15.9a | 10.9 | 3265 | 1.36 | 816 | 0.250 | synergy |
FICI = fractional inhibitory concentration index; synergy and antagonism were defined by FICI ≤ 0.5 and >4, respectively. Indifference was defined by 0.5 < FICI ≤ 4.