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. 2019 Jul 24;4(7):12584–12597. doi: 10.1021/acsomega.9b01106

Table 1. IC50 Values (μM) of 13, BMS-001, PARPi, and Olaparib against a Panel of Cancer Cell Lines after 7 Days of Exposurea.

cell line 1 2 3 BMS-001 PARPi olaparib
OVCAR8 13.62 ± 1.7 5.02 ± 0.3 6.29 ± 1.9 25.53 ± 0.15 25.5 ± 00.1 11.14 ± 5.4
MDA-MB-231 10.99 ± 6.7 9.51 ± 7.5 5.89 ± 5.6 14.83 ± 7.7 26.61 ± 1.13 14.00 ± 7.1
A2780 12.68 ± 8.6 5.82 ± 10.2 5.40 ± 3.42 24.26 ± 10.2 25.68 ± 8.4 9.32 ± 0.2
SKOV3 3.8 ± 34.48 5.13 ± 6.1 12.17 ± 0.43 24.36 ± 2.31 50.0 ± 70.1  
H460 13.6 ± 0.2 10.64 ± 0.48 5.91 ± 0.13 21.49 ± 0.19 28.57 ± 0.82 8.1 ± 1.2
HCC1937 10.79 ± 0.4 10.67 ± 0.59 5.26 ± 0.05 13.54 ± 0.11 20.77 ± 0.17 18.44 ± 2.4
a

Compounds were freshly prepared in DMSO and used immediately. DMSO concentration was <1%.