Table 1. IC50 Values (μM) of 1–3, BMS-001, PARPi, and Olaparib against a Panel of Cancer Cell Lines after 7 Days of Exposurea.
cell line | 1 | 2 | 3 | BMS-001 | PARPi | olaparib |
---|---|---|---|---|---|---|
OVCAR8 | 13.62 ± 1.7 | 5.02 ± 0.3 | 6.29 ± 1.9 | 25.53 ± 0.15 | 25.5 ± 00.1 | 11.14 ± 5.4 |
MDA-MB-231 | 10.99 ± 6.7 | 9.51 ± 7.5 | 5.89 ± 5.6 | 14.83 ± 7.7 | 26.61 ± 1.13 | 14.00 ± 7.1 |
A2780 | 12.68 ± 8.6 | 5.82 ± 10.2 | 5.40 ± 3.42 | 24.26 ± 10.2 | 25.68 ± 8.4 | 9.32 ± 0.2 |
SKOV3 | 3.8 ± 34.48 | 5.13 ± 6.1 | 12.17 ± 0.43 | 24.36 ± 2.31 | 50.0 ± 70.1 | |
H460 | 13.6 ± 0.2 | 10.64 ± 0.48 | 5.91 ± 0.13 | 21.49 ± 0.19 | 28.57 ± 0.82 | 8.1 ± 1.2 |
HCC1937 | 10.79 ± 0.4 | 10.67 ± 0.59 | 5.26 ± 0.05 | 13.54 ± 0.11 | 20.77 ± 0.17 | 18.44 ± 2.4 |
Compounds were freshly prepared in DMSO and used immediately. DMSO concentration was <1%.