Table 3.
Multivariable analysis for OS in patients who underwent salvage radiotherapy (n = 115)
| Variable | Hazard Ratio | 95% CI | P-value |
|---|---|---|---|
| Age (continuous) | 1.005 | 0.98–1.03 | 0.63 |
| RPA class | |||
| Class 1 | Reference | 0.63 | |
| Class 2 | 0.88 | 0.56–1.39 | 0.59 |
| Class 3 | 1.53 | 0.4–5.91 | 0.54 |
| Pattern of initial LMD | |||
| Nodular (vs classical) | 0.59 | 0.34–0.98 | 0.04 |
| Primary tumor type | |||
| NSCLC | Reference | 0.002 | |
| Breast | 0.69 | 0.36–1.32 | 0.26 |
| Melanoma | 2.4 | 1.12–5.17 | 0.03 |
| Gastrointestinal | 1.47 | 0.75–2.91 | 0.26 |
| Other | 0.42 | 0.18–1.01 | 0.054 |
| Type of RT salvage | |||
| Focal RT (vs WBRT) | 0.65 | 0.4–1.06 | 0.09 |
| Number of BM at initial SRS | |||
| 1 | Reference | 0.91 | |
| 2–4 | 0.91 | 0.55–1.5 | 0.71 |
| ≥5 | 1.07 | 0.41–2.78 | 0.89 |