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. 2019 Jun 26;11(4):89–101. doi: 10.1080/19382014.2019.1585165

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© 2019 The Author(s). Published with license by Taylor & Francis Group, LLC.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way.

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Figure 2. — Histological analysis of the expression of Cathelicidin (A-C), Alpha 1 (D-F) and Beta 2 (G-I). In (A), an islet with positive cells is visible in an ND donor. Singular positive cells are scattered throughout the exocrine tissue. The donor with recent onset T1D shows no Cathelicidin-positive cells in the biopsy with low grade immune-cell infiltration (D1_CD45lo) (B), whereas the biopsy from the same T1D donor with intense infiltration by immune cells (D1_CD45hi) shows multiple positive cells throughout the exocrine parenchyma and in endocrine tissue (C). In (D), Alpha 1-positive cells are spread throughout the exocrine parenchyma of an ND donor, whereas the parenchyma of D1_CD45lo is completely negative (E). Notably, D1_CD45hi (F) is similar to the ND donor (D). In (G), cells in the exocrine parenchyma as well as multiple islets of an ND donor show strong positivity for Beta 2. Only, singular Beta 2-positive cells can be seen in the exocrine parenchyma of D1_CD45lo (H), whereas D1_CD45hi shows strong positivity in exocrine and endocrine tissue (I).