Figure 2.

Accuracy of Five De Novo Variant Prediction Algorithms

Receiver operating characteristic (ROC) curves compare variant prediction performance on a simulated dataset. Average sequencing depth was approximately 30x. Each of the six panes shows prediction accuracy for a different variant type: SNVs, insertions or deletions (indels) 1–10 bp in length, 11- to 100-bp indels, 101- to 200-bp indels; 201- to 300-bp indels; and 301- to 400-bp indels. Note that the scale of the x axis for long indels is an order of magnitude smaller than the x axis scale for SNVs and short ($<$ 100 bp) indels.