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TAP1 protein expression on cervical carcinoma tissue visualized by immunohistochemistry (http://proteinatlas.org).
High expression of TAP1 facilitates the transport of cytosolic peptides into the endoplasmic reticulum (ER) and loading of those antigenic peptides onto HLA class I (HLA-I) molecules. When cancer cells down modulate the peptide pump TAP, it gives rise to the presentation of TEIPP antigens.
