Table 2.
Relationship between PD-L1 in tissue and other immune parameters.
| PD-L1 expression in Peritumoral immune cells |
p-valuea |
||||||
|---|---|---|---|---|---|---|---|
| ≤10% (n = 14) |
> 10% (n = 8) |
||||||
| BCG Responders (n = 8) |
BCG Nonresponders (n = 6) |
p- valueb |
BCG Responders (n = 4) |
BCG Nonresponders (n = 4) |
p-valueb | ||
| Age (years); median (IQR) | 63 (60–77) | 72 (61–78) | 0.6 | 74 (64–85) | 75 (68–84) | 1 | 0.12 |
| Absolute neutrophils count (x109/L); median (IQR) | 4.5 (3.3–4.8) | 4.6 (4–5.6) | 0.6 | 4 (2.8–5.1) | 5.4 (3–8.7) | 0.6 | 0.9 |
| Absolute lymphocyte count (x109/L); median (IQR) | 2.1 (1.7–2.5) | 2.1 (1.7–2.8) | 1 | 2 (1.4–2.6) | 1.2 (1.1–1.7) | 0.1 | 0.04 |
| NLR; median (IQR) | 1.8 (1.6–2.7) | 2 (1.8–2.6) | 0.5 | 2.3 (1.3–3) | 4.5 (2.7–5.2) | 0.1 | 0.07 |
| Total Peritumoral GATA-3+ cells; median (IQR) | 630 (400–1012) | 454(262–757) | 0.2 | 1105 (395–1173) | 662 (543–1420) | 0.9 | 0.18 |
| Total Peritumoral T-bet+ cells; median (IQR) | 125(38–192) | 235 (53–327) | 0.2 | 134 (50–239) | 265 (185–324) | 0.1 | 0.6 |
| GTR ratio; median (IQR) | 6.2 (3.6–12.5) | 2.5(1.5–6.8) | 0.08 | 8 (5.1–8.6) | 2.8 (2–6) | 0.06 | 0.9 |
aComparison of low PD-L1 expression (≤10%) and high PD-L1 expression (> 10%); bComparison of BCG responders and BCG nonresponders.