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. 2019 Apr 26;8(8):1601481. doi: 10.1080/2162402X.2019.1601481

Figure 7.

Figure 7.

VEGF-C levels are reduced in A2a-deficient sentinel lymph nodes.

WT and A2a-deficient mice were injected with 2.5 × 105 B16-CD73+ melanoma cells in the foot pad and two weeks later tumor-draining lymph nodes and contralateral lymph nodes were collected. Primary tumors and lymph node were homogenized, centrifuged and supernatants were assayed for VEGF levels by ELISA. (a) Fold-increase in VEGF-A, C and D in tumor-draining lymph nodes (TdLN) over matched contraleral lymph nodes (cLN). (b) Levels of VEGF-A, C and D in tumors. Means ± standard errors are shown. * p < 0.05, ** p < 0.01, *** p < 0.001, **** p < 0.0001 using a Student t test. Results of 2 independent experiments with 10 mice per group were pooled.