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. 2019 Jul 9;8:e46472. doi: 10.7554/eLife.46472

Figure 3. MA consumption and total volume consumed among BXD strains are strain-dependent.

Figure 3.

MA consumption when MA was offered vs. water for 18h/day at a concentration of (a) 20 mg/l or (b) 40 mg/l. (c) Total volume consumed from the water and MA tubes during the 18h period when MA was offered vs. water, collapsed on MA concentration, because there was no concentration-dependent effect. Presented are means (represented by bars) and individual data points (represented by circles) for data collapsed on sex. n = 5–28/strain tested in 4 cohorts of 27–97 mice. Repeated measures ANOVA, ###p<0.001 for the main effect of strain. BXD, C57BL/6J (B6) x DBA2/J (D2); MA, methamphetamine; Oprm1, mu opioid receptor gene; Oprm1B6/B6, homozygous for B6 Oprm1 allele; Oprm1D2/D2, homozygous for D2 Oprm1 allele; Taar1, trace amine-associated receptor 1 gene; Taar1+/+, homozygous for reference Taar1+ allele; Taar1m1J/m1J, homozygous for mutant Taar1m1J allele. The raw data represented in the graphs are available in Figure 3—source data 1.

Figure 3—source data 1. MA consumption (mg/kg/18h) and total volume consumed (ml/18h) data for male and female, BXD mice, according to Taar1 and Oprm1 genotype.
elife-46472-fig3-data1.xlsx (25.2KB, xlsx)
DOI: 10.7554/eLife.46472.008