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. 2019 Jul 9;8:e46472. doi: 10.7554/eLife.46472

Figure 4. MA consumption is impacted in BXD mice by a Taar1 x Oprm1 interaction.

Figure 4.

(a) MA consumption and (b) total volume consumed, when MA was offered vs. water for 18h/day at a concentration of 20 or 40 mg/l for BXD strain mice with different combined Taar1/Oprm1 genotypes. Presented are means (represented by bars) and individual data points (represented by circles) for data collapsed on sex. n = 52–71/ genotype tested in 4 cohorts of 27–97 mice. Repeated measures ANOVA, ###p<0.001 for the main effect of Taar1+/+ vs. Taar1m1J/m1J. Repeated measures ANOVA followed by simple main effects analysis, ***p<0.001 compared to Taar1+/+ with the same Oprm1 genotype; +++p < 0.001 compared to Taar1m1J/m1J/Oprm1B6/B6 at 40 mg/l MA. BXD, C57BL/6J (B6) x DBA2/J (D2); MA, methamphetamine; Oprm1, mu-opioid receptor gene; Oprm1B6/B6, homozygous for B6 Oprm1 allele; Oprm1D2/D2, homozygous for D2 Oprm1 allele; Taar1, trace amine-associated receptor 1 gene; Taar1+/+, homozygous for reference Taar1+ allele; Taar1m1J/m1J, homozygous for mutant Taar1m1J allele. The raw data represented in the graphs are available in Figure 4—source data 1.

Figure 4—source data 1. MA consumption (mg/kg/18h) and total volume consumed (ml/18h) data for male and female BXD mice, according to Taar1 and Oprm1 genotype.
elife-46472-fig4-data1.xlsx (26.4KB, xlsx)
DOI: 10.7554/eLife.46472.010