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. Author manuscript; available in PMC: 2019 Aug 5.
Published in final edited form as: Biochem Biophys Res Commun. 2019 Mar 26;512(4):729–735. doi: 10.1016/j.bbrc.2019.03.119

Figure 2.

Figure 2

Mass spectrometry metabolic analysis determined that MSCs exposed to hypoxia and serum deprivation significantly modulated amino acid, nucleoside, and carbohydrate metabolism based on chemical ontology analysis using the ChemRICH tool developed by Barupal et al (A). Analysis of metabolites associated with carbohydrate metabolism determined that primed MSCs downregulate several pathways related to aerobic respiration. N = 6 per condition. For ChemRICH analysis enrichment p-values are given by the Kolmogorov–Smirnov-test. For Kreb’s cycle analysis significance calculated with T-tests with a multi-testing correction analysis using a false discovery rate of 1%.