Table 3:

F (p) values for dependence, acceptability, and cotinine outcomes.

	VLNC vs CPD	Week	Condition × Week	Condition × Week (controlling for NRT patch use)	Condition × Week (controlling for % non-study cigarette/day)
Dependence
NDSS Overall Score	0 (.78)	13.9 (<.001)	3.2 (.018)	3.0 (.023)	1.0 (.41)
NDSS Drive	0.5 (.47)	14.7(<.001)	3.3 (.013)	3.5 (.011)	5.1 (.004)
NDSS Stereotypy	1.0 (.33)	1.4 (.24)	0.8 (.56)	0.9 (.45)	0.2 (.92)
NDSS Priority	0.6 (.43)	0.6 (.68)	0.6 (.68)	0.3 (.88)	0.7 (.63)
NDSS Tolerance	1.4 (.23)	0.9 (.46)	0.1 (.97)	0.2 (.92)	0.7 (.63)
NDSS Continuity	3.4 (.071)	0.8 (.50)	0.7 (.61)	0.5 (.76)	1.2 (.34)
FTCD without cigarettes/day	0.1 (.70)	4.4 (.003)	0.5 (.70)	0.4 (.79)	1.2 (.33)
GN-SBQ	0 (.94)	12.8 (<.001)	0.1 (.99)	0.2 (.93)	1.2 (.33)
Addiction Ladder	0 (.85)	24.1 (<.001)	2.4 (.049)	1.8 (.14)	0.5 (.75)
Acceptability
% Non-Study Cigarettes/Day	6.6 (.013)	26.3 (<.001)	8.0 (<.001)	29.5 (<.001)	-
Willingness to smoke number of cigarettes	10.4 (.002)	5.7 (<.001)	4.0 (.005)	6.0 (<.001)	-
Ability to smoke number of cigarettes	16.0 (<.001)	4.8 (.002)	3.5 (.009)	4.1 (.005)	-
Willingness to smoke type of cigarette	0.01 (.94)	0.2 (.92)	0.7 (.60)	0.5 (.75)	-
Ability to smoke type of cigarette	0.5 (.50)	1.0 (.44)	0.8 (.56)	0.4 (.80)	-
Nicotine Exposure
Cotinine	8.3 (.005)	5.3 (<.001)	7.7 (<.001)	9.3 (<.001)	2.3 (.094)

CPD=Condition that reduced cigarettes per day; FTCD=Fagerstrom Test for Cigarette Dependence; GN-SBQ=Glover-Nilsson Smoking Behavioral Questionnaire; NDSS=Nicotine Dependence Syndrome Scale; NRT=Nicotine replacement therapy; VLNC=Condition that switched to very low nicotine content cigarettes; Bold findings represents primary outcomes. See Table S4 for covariance structures and Table S9 for mean dependence, acceptability, and cotinine outcomes.