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. Author manuscript; available in PMC: 2020 Aug 1.
Published in final edited form as: Dig Liver Dis. 2019 Apr 16;51(8):1154–1163. doi: 10.1016/j.dld.2019.03.020

Figure 3.

Figure 3.

SphK2 deficiency promotes a hepatic inflammatory response. (A) Representative images of immunofluorescence staining against CD11b and F4/80 with DAPI as a counterstain are shown. (B and C) Total liver RNA was isolated. Relative mRNA levels of target genes in WT and SphK2−/− mice on a 60-day control diet or 5% alcohol Lieber-DeCarli diet were determined using quantitative RT-PCR and normalized to Hprt1 as an internal control. Results are represented as mean ± SE from each group (n = 7). Statistical significance relative to the WT group, *P < 0.05; ***P < 0.001.