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. Author manuscript; available in PMC: 2020 Sep 1.
Published in final edited form as: Hum Immunol. 2019 Feb 5;80(9):633–643. doi: 10.1016/j.humimm.2019.01.010

Figure 1:

Figure 1:

Figure 1 shows the flow of concepts behind the software suite. Detailed description of each step with the section numbers and titles can be found in Materials and Methods. HaplObserve, HLAHapV and pould were developed and updated to accomplish: [1] building HLA haplotypes from families (light gray highlight: sections 2.2.2.1 – 2.2.2.7); [2] validating the haplotypes (dark gray highlight: 2.2.2.7 – 2.3.2); [3] calculating haplotype frequencies (2.4); [4] estimating measures of LD from the family haplotypes (2.5).