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. 2019 Jul 24;10(7):247–255. doi: 10.5306/wjco.v10.i7.247

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©The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.

This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial.

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Tumor biopsy before and after treatment with nivolumab. A: Pretreatment tumor biopsy in 2012, HE-stain. Note the intratumoral lymphocytes (TILS); B: Posttreatment tumor biopsy of the high-grade serous carcinoma of the left colic flexure in 2016, HE-stain. Note reduced intratumoral lymphocytes.