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. 2019 Jul 15;11(14):4943–4969. doi: 10.18632/aging.102089

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Copyright © 2019 Yu et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution (CC BY) 3.0 License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Increase in the levels of D-ribose and related enzymes in type 1 diabetic rats. Male SD rats (6–8 weeks) were intraperitoneally injected with STZ (70 mg/kg bw, n=30) and maintained for 10 weeks. Rats injected with saline were used as controls (n=10). Levels of D-ribose in urine were measured at different time intervals (panel A). D-ribose levels in serum (panel B) and the brain (panel C) were determined within 3 days after dissection. The expression and activity levels of ribokinase, transketolase (TKT), 5-phosphoribosyl 1-pyrophosphate (PRPP) and glucose-6 phosphate dehydrogenase (G6PD) in the brain were measured with ELISA kits (panel D and E). All values are expressed as the mean ± S.E.M. *, P < 0.05; **, P < 0.01; ***, P < 0.001.