Table 3. Univariate and multivariate Cox regression analyses of overall survival in cervical cancer patients.
Parameter | Univariate analysis | Multivariate analysis | ||||
---|---|---|---|---|---|---|
P | HR | 95% CI | P | HR | 95% CI | |
Age (y) | ||||||
(≤50 vs. >50) | 0.097 | 1.551 | 0.923–2.606 | |||
Clinical stage | ||||||
(I-IIA vs. IIB-IV) | <0.001 | 2.950 | 1.669–5.213 | 0.437 | 0.667 | 0.241–1.850 |
Tumor size (cm) | ||||||
(≤4 vs. >4) | 0.610 | 0.877 | 0.530–1.452 | |||
Lymph node metastasis | ||||||
(Absent vs. Present) | <0.001 | 4.036 | 2.331–6.987 | 0.123 | 2.190 | 0.809–5.926 |
Distant metastasis | ||||||
(Absent vs. Present) | 0.001 | 3.148 | 1.607–6.169 | 0.005 | 0.188 | 0.059–0.601 |
HPV | ||||||
(Absent vs. Present) | 0.363 | 1.287 | 0.747–2.216 | |||
Histological type | ||||||
(Adenocarcinoma vs. Squamous cell carcinoma) | <0.001 | 0.219 | 0.210–0.400 | 0.001 | 0.156 | 0.054–0.451 |
Histological grade | ||||||
(Well vs. Moderately/Poorly) | <0.001 | 6.664 | 3.355–13.238 | <0.001 | 4.133 | 1.911–8.937 |
TP73 protein expression | ||||||
(Low vs. High) | <0.001 | 0.240 | 0.137–0.421 | 0.039 | 0.505 | 0.263–0.967 |
Abbreviations: HR, hazard ratio; 95% CI, 95% confidence interval.