Table 3.
Outcome Markers in the 2 Arms of the Study∗
| Echocardiographic Optimization | SD | Hemodynamic Optimization | SD | Difference | n | |
|---|---|---|---|---|---|---|
| MLWHFQ score | 36 | 24 | 37 | 24 | 1.0 | 268 |
| SF36v2 physical component score | 38 | 10 | 39 | 10 | 1.0 | 269 |
| LVEDD, mm | 58 | 11 | 58 | 9 | 0 | 284 |
| LVESD, mm | 49 | 12 | 48 | 11 | 1.0 | 284 |
| Peak VO2, ml/kg/min | 14.5 | 4.5 | 14.6 | 4.7 | 0.1 | 250 |
| NT-proBNP, pg/ml | 1,338 | 2,585 | 1,348 | 2,723 | 10.0 | 262 |
| Log10 NT-proBNP, log10 pg/ml | 2.8 | 0.6 | 2.8 | 0.6 | 0 | 262 |
LVEDD = left ventricular end-diastolic dimension; LVESD = left ventricular end-systolic dimension; MLWHFQ = Minnesota Living With Heart Failure questionnaire; NT-proBNP = N-terminal pro–B-type natriuretic peptide; SD = standard deviation; SF36v2 = 36-Item Short Form Health Survey version 2; VO2 = oxygen uptake.
∗
Scores (with SD) are listed for all the primary and secondary outcomes measures for the study following 6 months of randomization in each arm.