Table 4.

Cox multivariable analysis of melanoma-specific and recurrence-free survival

Factor	Value	Melanoma-specific survival			Recurrence-free survival
		HR	95% CI	p value	HR	95% CI	p value
Managementa	Observation	0.94	0.56–1.60	0.83	1.07	0.74–1.54	0.73
Sex	Male	1.42	1.12–1.80	0.004	1.25	1.05–1.49	0.01
Age	Per year	1.01	0.997–1.01	0.20	1.01	1.00–1.01	0.004
Melanoma location (reference: head and neck)	Upper limb	0.72	0.52–0.99	0.045	0.81	0.64–1.03	0.09
	Lower limb	0.84	0.61–1.15	0.27	0.98	0.78–1.25	0.89
	Trunk	0.94	0.70–1.14	0.65	0.72	0.57–0.91	0.005
Breslow thickness, mm (reference: 0–1 mm)	1.01–2	1.66	0.88–3.12	0.12	1.42	0.95–2.13	0.09
	2.01–4	3.14	1.67–5.89	< 0.001	2.46	1.63–3.69	< 0.001
	> 4	5.38	2.83–10.24	< 0.001	3.69	2.42–5.64	< 0.001
Tumor mitotic rate (reference: 0)	≥ 1	2.91	1.36–6.22	0.006	1.98	1.26–3.13	0.003
Ulceration	Present	1.71	1.37–2.13	< 0.001	1.62	1.36–1.92	< 0.001

HR hazard ratio, CI confidence interval

^aSentinel node biopsy versus observation