Table 2.

Proposed synergistic effects of protease inhibitors (PI) to docetaxel treatment examined in in vitro studies

Cell line	PI	Proposed effect	References
NCI-H460 NCI-H520	Nelfinavir	Nelfinavir-induced inhibition of Akt signaling leading to more sensitivity to docetaxel	[114]
DU145 cell line	Ritonavir	Increased effect of docetaxel on activation of caspase-3 and cleavage of PARP	[99]
DU145 cell line	Ritonavir	Reduced DNA-binding activity of NFκB, surpassing one resistance mechanism of docetaxel	[99]
DU145 cell line	Ritonavir	Blocked the docetaxel-induced increase in CYP3A4 mRNA, decreasing the metabolism of docetaxel	[99]