Fig. 6.

Schematic illustration of the role of CD8⁺NKT-like cells in the tumor microenvironment. a In the tumor microenvironment, the increased number of MDSCs produce arginase I, TGF-β, NO, or IL-10, leading to the inhibition of antitumor immune responses. b The adaptive transfer of CD8⁺NKT-like cells may result in the killing of tumor cells and tumor antigen-loaded MDSCs, thereby leading to an improvement of the antitumor microenvironment and elimination of tumors